Divinyl sulfone → 4-(3-Hydroxypropyl)thiomorpholine 1,1-Dioxide
反応式
[NH2:1][CH2:2][CH2:3][CH2:4][OH:5].[CH:6]([S:8]([CH:11]=[CH2:12])(=[O:10])=[O:9])=[CH2:7]>>[O:9]=[S:8]1(=[O:10])[CH2:11][CH2:12][N:1]([CH2:2][CH2:3][CH2:4][OH:5])[CH2:7][CH2:6]1参加物
3
反応条件
- 温度
- 110 °C
実験手順
A mixture of 3-amino-1-propanol (650 μl, 8.4 mmol) and vinyl sulphone (1 g, 8.4 mmol) was heated at 110° C. for 45 minutes. The mixture was allowed to cool and was purified by column chromatography eluting with methylene chloride/methanol (95/5) to give 3-(1,1-dioxothiomorpholino)-1-propanol (800 mg, 90%).
後処理
- temperatureto cool
- customwas purified by column chromatography
- washeluting with methylene chloride/methanol (95/5)
出典と根拠
- ORDレコード
- ord-792282f4cc3347129e555ff455a202f4
- 出典データセット
- uspto-grants-2013_07
- 特許番号
- US08492560B2
反応ノート
読み込み中…