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1,2-Dibromoethane → 6-(2-Bromoethoxy)salicylamide
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 1,2-Dibromoethane | HCID 7839 | — |
| 反応物 | Potassium Carbonate | HCID 11430 | — |
| 反応物 | 2,6-Dihydroxybenzamide | HCID 76602 | — |
| 溶媒 | Acetonitrile | HCID 6342 | — |
| 生成物 | 6-(2-Bromoethoxy)salicylamide | HCID 13754423 | — |
反応手順
A mixture of 23.0 g of 2,6-dihydroxybenzamide, 20.7 g of potassium carbonate and 28.2 g of 1,2-dibromoethane is refluxed, whilst stirring, for 2-3 hours in 300 ml of acetonitrile. The reaction mixture is filtered whilst still warm, the filtrate concentrated by evaporation and the residue recrystallised from a little methanol. 6-(2-Bromoethoxy)salicylamide having a melting point of 120°-121° is obtained.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04727067 |
| 出典データセット | uspto-grants-1988_02 |
| ORD ID | ord-2158019772d240b48c99ecea1fc7c2f3 |
| 出典メモ | uspto-grants-1988_02 |