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4-Benzylbenzoic acid → N-Benzyl-2-(4-benzylbenzamido)-4-((methylamino)methyl)thiazole-5-carboxamide
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 4-Benzylbenzoic acid | HCID 136429 | — |
| 反応物 | 2-amino-N-benzyl-4-((methylamino)methyl)thiazole-5-carboxamide | HCID 86642526 | — |
| 生成物 | N-Benzyl-2-(4-benzylbenzamido)-4-((methylamino)methyl)thiazole-5-carboxamide | HCID 59369653 | — |
反応手順
Following the procedure as described in Example 22, making variation only as required to use 2-amino-N-benzyl-4-((methylamino)methyl)thiazole-5-carboxamide in place of 2-amino-N-benzyl-4-((diethylamino)methyl)thiazole-5-carboxamide to react with 4-benzylbenzoic acid, the title compound was obtained; 1H NMR (CD3OD, 400 MHz) δ 7.93 (d, J=8.6 Hz, 2H), 7.35-7.15 (m, 12H), 4.49 (s, 2H), 4.06 (s, 2H), 4.02 (s, 2H), 3.09 (s, 2H), 2.37 (s, 3H); MS (ES+) m/z 471 (M+1).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08541457B2 |
| 出典データセット | uspto-grants-2013_09 |
| ORD ID | ord-4549abaaf6b6470a897475084baa2be9 |
| 出典メモ | uspto-grants-2013_09 |