4-Benzylbenzoic acid → N-Benzyl-2-(4-benzylbenzamido)-4-((methylamino)methyl)thiazole-5-carboxamide

HRID 45401

反応式

HRID 45401 の反応式
[NH2:1][C:2]1[S:3][C:4]([C:10]([NH:12][CH2:13][C:14]2[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=2)=[O:11])=[C:5]([CH2:7][NH:8][CH3:9])[N:6]=1.[CH2:20]([C:27]1[CH:35]=[CH:34][C:30]([C:31](O)=[O:32])=[CH:29][CH:28]=1)[C:21]1[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=1>>[CH2:13]([NH:12][C:10]([C:4]1[S:3][C:2]([NH:1][C:31](=[O:32])[C:30]2[CH:29]=[CH:28][C:27]([CH2:20][C:21]3[CH:22]=[CH:23][CH:24]=[CH:25][CH:26]=3)=[CH:35][CH:34]=2)=[N:6][C:5]=1[CH2:7][NH:8][CH3:9])=[O:11])[C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=1

参加物

3

反応物 2

HCID 1364294-Benzylbenzoic acidHCID 866425262-amino-N-benzyl-4-((methylamino)methyl)thiazole-5-carboxamide

生成物 1

HCID 59369653N-Benzyl-2-(4-benzylbenzamido)-4-((methylamino)methyl)thiazole-5-carboxamide

実験手順

Following the procedure as described in Example 22, making variation only as required to use 2-amino-N-benzyl-4-((methylamino)methyl)thiazole-5-carboxamide in place of 2-amino-N-benzyl-4-((diethylamino)methyl)thiazole-5-carboxamide to react with 4-benzylbenzoic acid, the title compound was obtained; 1H NMR (CD3OD, 400 MHz) δ 7.93 (d, J=8.6 Hz, 2H), 7.35-7.15 (m, 12H), 4.49 (s, 2H), 4.06 (s, 2H), 4.02 (s, 2H), 3.09 (s, 2H), 2.37 (s, 3H); MS (ES+) m/z 471 (M+1).

出典と根拠

ORDレコード
ord-4549abaaf6b6470a897475084baa2be9
出典データセット
uspto-grants-2013_09
特許番号
US08541457B2

関連ノート

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