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5-Hydroxyindole → 4-(Indol-5-yloxy)-6-methoxy-7-(3-piperidinopropoxy)quinazoline
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 5-Hydroxyindole | HCID 16054 | — |
| 反応物 | 4-Chloro-6-methoxy-7-(3-(piperidin-1-YL)propoxy)quinazoline | HCID 11002191 | — |
| 生成物 | 4-(Indol-5-yloxy)-6-methoxy-7-(3-piperidinopropoxy)quinazoline | HCID 22030732 | 45% |
反応手順
Using an analogous procedure to that described in Example 67, 4-chloro-6-methoxy-7-(3-piperidinopropoxy)quinazoline (100 mg), (prepared as described for the starting material in Example 67), was reacted with 5-hydroxyindole (48 mg, 0.36 mmol) to give 4-(indol-5-yloxy)-6-methoxy-7-(3-piperidinopropoxy)quinazoline (57 mg, 45%).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08492560B2 |
| 出典データセット | uspto-grants-2013_07 |
| ORD ID | ord-303593c4d770439299460059c65a4648 |
| 出典メモ | uspto-grants-2013_07 |