Methanol → 3-Fluoro-7-hydroxy-2-methylquinoline
反応式
[F:1][C:2]1[C:3]([CH3:14])=[N:4][C:5]2[C:10]([CH:11]=1)=[CH:9][CH:8]=[C:7]([O:12]C)[CH:6]=2.B(Br)(Br)Br.CO>ClCCl>[F:1][C:2]1[C:3]([CH3:14])=[N:4][C:5]2[C:10]([CH:11]=1)=[CH:9][CH:8]=[C:7]([OH:12])[CH:6]=2参加物
5
実験手順
3-Fluoro-7-methoxy-2-methylquinoline (0.16 g, 0.85 mmol) was taken up in dichloromethane (4 ml) under nitrogen and treated with boron tribromide solution (4 ml of a 1.0M solution in dichloromethane, 4.0 mmol). The reaction was stirred for 24 hours at ambient temperature followed by the slow addition of excess methanol. The solution was stirred for a further 2 hours and then evaporated to dryness to give 3-fluoro-7-hydroxy-2-methylquinoline which was used without further purification.
後処理
- stirringThe solution was stirred for a further 2 hours
- customevaporated to dryness
出典と根拠
- ORDレコード
- ord-1671a113e0e84df59dd109665832c08a
- 出典データセット
- uspto-grants-2013_07
- 特許番号
- US08492560B2
反応ノート
読み込み中…