化工社化工社 化学情報印刷レポート · 研究参考用
2-Methyl-5-nitro-1H-indole → 5-Amino-2-methylindole
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 2-Methyl-5-nitro-1H-indole | HCID 280313 | — |
| 反応物 | HCID 178418361 | HCID 178418361 | — |
| 触媒 | Palladium | HCID 23938 | — |
| 溶媒 | Ethanol | HCID 702 | — |
| 溶媒 | Tetrahydrofuran | HCID 8028 | — |
| 生成物 | 5-Amino-2-methylindole | HCID 2733992 | 99.6% |
反応手順
A solution of 2-methyl-5-nitroindole (1 g, 5.7 mmol) in ethanol (25 ml) and THF (25 ml) containg 10% palladium on charcoal (128 mg) was hydrogenated until uptake of hydrogen ceased. The mixture was filtered and the filtrate was evaporated to give 5-amino-2-methylindole (830 mg, quant.).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08492560B2 |
| 出典データセット | uspto-grants-2013_07 |
| ORD ID | ord-fa041f888df349298ff5b641bf002f5e |
| 出典メモ | uspto-grants-2013_07 |