Ammonia → 7-(2-(1-Methylpiperidin-4-yl)ethoxy)-6-methoxy-3,4-dihydroquinazolin-4-one

HRID 454229ノート

反応式

HRID 454229 の反応式
[CH3:1][N:2]1[CH2:7][CH2:6][CH:5]([CH2:8][CH2:9][O:10][C:11]2[CH:20]=[C:19]3[C:14]([C:15](=[O:29])[N:16](COC(=O)C(C)(C)C)[CH:17]=[N:18]3)=[CH:13][C:12]=2[O:30][CH3:31])[CH2:4][CH2:3]1.N>CO>[CH3:1][N:2]1[CH2:7][CH2:6][CH:5]([CH2:8][CH2:9][O:10][C:11]2[CH:20]=[C:19]3[C:14]([C:15](=[O:29])[NH:16][CH:17]=[N:18]3)=[CH:13][C:12]=2[O:30][CH3:31])[CH2:4][CH2:3]1

参加物

4

反応物 2

HCID 222AmmoniaHCID 111128387-(2-(1-Methylpiperidin-4-yl)ethoxy)-6-methoxy-3-((pivaloyloxy)methyl)-3,4-dihydroquinazolin-4-one

生成物 1

HCID 1354507917-(2-(1-Methylpiperidin-4-yl)ethoxy)-6-methoxy-3,4-dihydroquinazolin-4-one収率 101.3%

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

A solution of 7-(2-(1-methylpiperidin-4-yl)ethoxy)-6-methoxy-3-((pivaloyloxy)methyl)-3,4-dihydroquinazolin-4-one (4.2 g, 9.7 mmol) in methanol saturated with ammonia (150 ml) was stirred overnight at ambient temperature. The volatiles were removed under vacuum and the residue was triturated with ether. The solid was filtered, washed with ether and dried under vacuum to give 7-(2-(1-methylpiperidin-4-yl)ethoxy)-6-methoxy-3,4-dihydroquinazolin-4-one (3.12 g, 100%).

後処理

  1. customThe volatiles were removed under vacuum
  2. customthe residue was triturated with ether
  3. filtrationThe solid was filtered
  4. washwashed with ether
  5. customdried under vacuum

出典と根拠

ORDレコード
ord-62367d55a4c8443d9dd6f4fb3ad701cb
出典データセット
uspto-grants-2013_07
特許番号
US08492560B2

反応ノート

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