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Sodium hydride → 2-[2-(3-Fluoropropoxy)pyrimidine-4-yl]-6-methoxybenzothiophene
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Sodium hydride | HCID 24758 | — |
| 反応物 | 3-Fluoro-1-propanol | HCID 68042 | — |
| 反応物 | 2-(2-Chloropyrimidine-4-yl)-6-methoxybenzothiophene | HCID 86646555 | — |
| 生成物 | 2-[2-(3-Fluoropropoxy)pyrimidine-4-yl]-6-methoxybenzothiophene | HCID 46947547 | 65.4% |
反応手順
2-[2-(3-Fluoropropoxy)pyrimidine-4-yl]-6-methoxybenzothiophene (1-32, 75 mg, 65%) was prepared in the same manner as in Example 31 as a pale yellow solid using 3-fluoro-1-propanol (40 mL, 0.54 mmol), sodium hydride (NaH, 22 mg, 0.54 mmol) and 2-(2-chloropyrimidine-4-yl)-6-methoxybenzothiophene (105a, 100 mg, 0.36 mmol) obtained in Preparation Example 19.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08497260B2 |
| 出典データセット | uspto-grants-2013_07 |
| ORD ID | ord-7174684f3c7f4527b7c6cfe771d1f13c |
| 出典メモ | uspto-grants-2013_07 |