Hydrochloric Acid → HCID 67477378、化合物

HRID 454887ノート

反応式

HRID 454887 の反応式
[N:1]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[CH:4]=[CH:3][C:2]=1[N:11]1[CH2:14][CH:13]([NH:15]C(=O)OC(C)(C)C)[CH2:12]1.[ClH:23]>CO>[ClH:23].[N:1]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[CH:4]=[CH:3][C:2]=1[N:11]1[CH2:12][CH:13]([NH2:15])[CH2:14]1

参加物

4

反応物 2

HCID 313Hydrochloric AcidHCID 58547859HCID 58547859、化合物

生成物 1

HCID 67477378HCID 67477378、化合物収率 96%

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

To tert-butyl (1-(quinolin-2-yl)azetidin-3-yl)carbamate (0.8 g, 2.9 mmol) was added 4 M HCl in MeOH (20 mL). The reaction mixture was stirred at room temperature for 30 min and concentrated. The remained solid was dried under high vacuum to give 1-(quinolin-2-yl)azetidin-3-amine hydrochloride (557 mg, 2.8 mmol, 96% yield) as a white solid. ESI-MS (M+1): 200 calc. for C12H13N3 199.

後処理

  1. concentrationconcentrated
  2. customThe remained solid was dried under high vacuum

出典と根拠

ORDレコード
ord-add817567b9749c7acd555cdcc4365ad
出典データセット
uspto-grants-2013_07
特許番号
US08497265B2

反応ノート

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