Hydrochloric Acid → (βR)-β-Amino-4-bromobenzeneethanol
反応式
C(OC(=O)[NH:7][C@H:8]([C:11]1[CH:16]=[CH:15][C:14]([Br:17])=[CH:13][CH:12]=1)[CH2:9][OH:10])(C)(C)C.Cl>CO.O1CCOCC1>[NH2:7][C@H:8]([C:11]1[CH:16]=[CH:15][C:14]([Br:17])=[CH:13][CH:12]=1)[CH2:9][OH:10]参加物
5
実験手順
A solution of [(R)-1-(4-bromo-phenyl)-2-hydroxy-ethyl]-carbamic acid t-butyl ester (946 mg, 3 mmol) in MeOH (15 ml) was treated with HCl in dioxane (4 M, 15 ml) for 1.5 h. The mixture was concentrated to give the titled compound (755 mg, 100%) as a white solid.
後処理
- concentrationThe mixture was concentrated
出典と根拠
- ORDレコード
- ord-a73a874f4f6e4c08883a880458021e51
- 出典データセット
- uspto-grants-2013_07
- 特許番号
- US08497271B2
反応ノート
読み込み中…