2-Pyrrolidone → 1-(6,8-Dichloro-2-p-tolyl-imidazo[1,2-a]pyridin-3-ylmethyl)-pyrrolidin-2-one
反応式
Cl.[Cl:2][C:3]1[CH:4]=[C:5]([Cl:21])[C:6]2[N:7]([C:9]([CH2:19]Cl)=[C:10]([C:12]3[CH:17]=[CH:16][C:15]([CH3:18])=[CH:14][CH:13]=3)[N:11]=2)[CH:8]=1.[NH:22]1[CH2:26][CH2:25][CH2:24][C:23]1=[O:27]>>[Cl:2][C:3]1[CH:4]=[C:5]([Cl:21])[C:6]2[N:7]([C:9]([CH2:19][N:22]3[CH2:26][CH2:25][CH2:24][C:23]3=[O:27])=[C:10]([C:12]3[CH:17]=[CH:16][C:15]([CH3:18])=[CH:14][CH:13]=3)[N:11]=2)[CH:8]=1参加物
3
実験手順
The title compound was prepared according to Method B and the experimentals described for compound 91 from 6,8-dichloro-3-(chloromethyl)-2-p-tolylimidazo[1,2-a]pyridine hydrochloride and pyrrolidin-2-one. m/e+ 374 for C19H18Cl2N3O [M+H]+; 1H-NMR (300 MHz, CDCl3) δ 8.49 (d, J=1.5 Hz, 1H), 7.63 (d, J=8.1 Hz, 2H), 7.33 (m, 3H), 4.93 (s, 2H), 3.11 (t, J=6.9 Hz, 2H), 2.43 (m, 5H), 1.92 (m, 2H) ppm.
出典と根拠
- ORDレコード
- ord-7c9e1de89ed744c9903a04550a80641d
- 出典データセット
- uspto-grants-2013_07
- DOI