Hydrochloric Acid → 1-[2,2-Bis-(4-chloro-phenyl)-ethyl]-piperazine

HRID 45506ノート

反応式

HRID 45506 の反応式
C(OC([N:8]1[CH2:13][CH2:12][N:11]([CH2:14][CH:15]([C:23]2[CH:28]=[CH:27][C:26]([Cl:29])=[CH:25][CH:24]=2)[C:16]2[CH:21]=[CH:20][C:19]([Cl:22])=[CH:18][CH:17]=2)[CH2:10][CH2:9]1)=O)(C)(C)C.Cl>C(OCC)(=O)C>[Cl:29][C:26]1[CH:25]=[CH:24][C:23]([CH:15]([C:16]2[CH:17]=[CH:18][C:19]([Cl:22])=[CH:20][CH:21]=2)[CH2:14][N:11]2[CH2:10][CH2:9][NH:8][CH2:13][CH2:12]2)=[CH:28][CH:27]=1

参加物

4

反応物 2

HCID 313Hydrochloric AcidHCID 593319524-[2,2-Bis-(4-chloro-phenyl)-ethyl]-piperazine-1-carboxylic acid tert-butyl ester

生成物 1

HCID 593319411-[2,2-Bis-(4-chloro-phenyl)-ethyl]-piperazine

試薬・触媒・溶媒 1

HCID 8857Ethyl Acetate溶媒

実験手順

4-[2,2-Bis-(4-chloro-phenyl)-ethyl]-piperazine-1-carboxylic acid tert-butyl ester was treated with HCl in ethyl acetate (saturated, 5 ml) for 1 hour, solvent removed under reduced pressure to afford the title compound as the HCl salt

後処理

  1. customsolvent removed under reduced pressure

出典と根拠

ORDレコード
ord-8ced5fbea95245feb462cf7eefb7ef31
出典データセット
uspto-grants-2013_09
特許番号
US08541461B2

反応ノート

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