4,5-Dimethylthiazole-2(3H)-thione → 4,5-Dimethyl-3-(6-methyl-2-p-tolyl-imidazo[1,2-a]pyridin-3-ylmethyl)-3H-thiazole-2-thione

関与物質

反応手順

The title compound was prepared according to Method A and the experimentals described for compound 92 from 3-(chloromethyl)-6-methyl-2-p-tolylimidazo[1,2-a]pyridine hydrochloride and 4,5-dimethylthiazole-2(3H)-thione. m/e+ 380 for C21H22N3S2 [M+H]+; 1H-NMR (400 MHz, CDCl3) δ 7.96 (s, 1H), 7.65 (d, J=8.0 Hz, 2H), 7.55 (d, J=8.8 Hz, 1H), 7.26 (d, J=8.0 Hz, 2H), 7.08 (dd, J=1.4, 9.1 Hz, 1H), 4.83 (s, 2H), 2.39 (s, 3H), 2.35 (s, 3H), 2.29 (s, 3H), 2.28 (s, 3H) ppm; 13C-NMR (100 MHz, CDCl3, δ) 156.250, 149.085, 145.149, 144.391, 137.642, 131.159, 129.347, 128.748, 128.217, 127.929, 122.090, 121.794, 116.828, 113.612, 30.301, 21.308, 18.449, 14.688, 11.374 ppm.

情報源と証拠