3-Amino-1,2,4-triazine → (6-Methyl-2-p-tolyl-imidazo[1,2-a]pyridin-3-ylmethyl)-[1,2,4]triazin-3-yl-amine

HRID 455080

反応式

HRID 455080 の反応式
Cl.Cl[CH2:3][C:4]1[N:8]2[CH:9]=[C:10]([CH3:13])[CH:11]=[CH:12][C:7]2=[N:6][C:5]=1[C:14]1[CH:19]=[CH:18][C:17]([CH3:20])=[CH:16][CH:15]=1.[N:21]1[CH:26]=[CH:25][N:24]=[C:23]([NH2:27])[N:22]=1>>[CH3:13][C:10]1[CH:11]=[CH:12][C:7]2[N:8]([C:4]([CH2:3][NH:27][C:23]3[N:22]=[N:21][CH:26]=[CH:25][N:24]=3)=[C:5]([C:14]3[CH:19]=[CH:18][C:17]([CH3:20])=[CH:16][CH:15]=3)[N:6]=2)[CH:9]=1

参加物

3

反応物 2

HCID 707153-Amino-1,2,4-triazineHCID 670287243-(Chloromethyl)-6-methyl-2-p-tolylimidazo[1,2-a]pyridine hydrochloride

生成物 1

HCID 67029154(6-Methyl-2-p-tolyl-imidazo[1,2-a]pyridin-3-ylmethyl)-[1,2,4]triazin-3-yl-amine

実験手順

The title compound was prepared according to Method A and the experimentals described for compound 139 from 3-(chloromethyl)-6-methyl-2-p-tolylimidazo[1,2-a]pyridine hydrochloride and 1,2,4-triazin-3-amine. m/e+ 331 for C19H19N6 [M+H]+; 1H-NMR (400 MHz, CDCl3) δ 8.60 (d, J=2.2 Hz, 1H), 8.04 (s, 1H), 8.00 (d, J=2.2 Hz, 1H), 7.86 (s, 1H), 7.64 (d, J=8.0 Hz, 2H), 7.53 (d, J=9.1 Hz, 1H), 7.22 (d, J=8.0 Hz, 2H), 7.05 (dd, J=1.4, 9.1 Hz, 1H), 5.11 (s, 2H), 2.37 (s, 3H), 2.27 (s, 3H) ppm.

出典と根拠

ORDレコード
ord-5262c0e9ab274b7ea018fbee2b89a677
出典データセット
uspto-grants-2013_07
特許番号
US08497278B2

関連ノート

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