4-Hydroxypyrrolidine → 1-(6-((2-(4-Chlorophenyl)imidazo[1,2-a]pyridin-3-yl)methyl)pyrazin-2-yl)pyrrolidin-3-ol

HRID 455112

反応式

HRID 455112 の反応式
ClC1C=CC2N(C(CNC3N=C([N:25]4[CH2:30][CH2:29][C:28]([CH3:32])([OH:31])CC4)C=CN=3)=C(C3C=CC=CC=3)N=2)C=1.[Cl:33][C:34]1[CH:39]=[CH:38][C:37]([C:40]2[N:41]=[C:42]3[CH:47]=[CH:46][CH:45]=[CH:44][N:43]3[C:48]=2[CH2:49][C:50]2[CH:55]=[N:54][CH:53]=[C:52](Cl)[N:51]=2)=[CH:36][CH:35]=1.N1CCC(O)C1>>[Cl:33][C:34]1[CH:39]=[CH:38][C:37]([C:40]2[N:41]=[C:42]3[CH:47]=[CH:46][CH:45]=[CH:44][N:43]3[C:48]=2[CH2:49][C:50]2[N:51]=[C:52]([N:25]3[CH2:30][CH2:29][CH:28]([OH:31])[CH2:32]3)[CH:53]=[N:54][CH:55]=2)=[CH:36][CH:35]=1

参加物

4

反応物 3

HCID 982104-HydroxypyrrolidineHCID 670290991-(2-((6-Chloro-2-phenylimidazo[1,2-a]pyridin-3-yl)methylamino)pyrimidin-4-yl)-4-methylpiperidin-4-olHCID 866551242-(4-Chlorophenyl)-3-((6-chloropyrazin-2-yl)methyl)imidazo[1,2-a]pyridine

生成物 1

HCID 670289051-(6-((2-(4-Chlorophenyl)imidazo[1,2-a]pyridin-3-yl)methyl)pyrazin-2-yl)pyrrolidin-3-ol

実験手順

The title compound was prepared according to the experimental for compound 187 from 2-(4-chlorophenyl)-3-((6-chloropyrazin-2-yl)methyl)imidazo[1,2-a]pyridine and pyrrolidin-3-ol. M/e+ 406 for C22H21ClN5O (M+H)−; 1H-NMR (400 MHz, CDCl3) δ 8.20 (d, J=6.2 Hz, 1H), 7.89 (d, J=8.4 Hz, 2H), 7.71 (d, J=10.6 Hz, 2H), 7.59 (dd, J=9.1, 0.7 Hz, 1H), 7.41 (d, J=8.4 Hz, 2H), 7.16 (m, 1H), 6.77 (t, J=6.9 Hz, 1H), 4.56 (s, 1H), 4.32 (s, 2H), 4.06 (m, 1H), 3.53 (m, 3H), 3.00 (bs, 1H), 2.04 (m, 2H) ppm.

出典と根拠

ORDレコード
ord-7d5ca89ac59d43a59a571690b0b2dd20
出典データセット
uspto-grants-2013_07
特許番号
US08497278B2

関連ノート

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