化工社化工社 化学情報印刷レポート · 研究参考用
2-(Methylamino)ethanol → 2-((6-((2-(4-Chlorophenyl)imidazo[1,2-a]pyridin-3-yl)methyl)pyrazin-2-yl)(methyl)amino)ethanol
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 2-(Methylamino)ethanol | HCID 8016 | — |
| 反応物 | 1-(2-((6-Chloro-2-phenylimidazo[1,2-a]pyridin-3-yl)methylamino)pyrimidin-4-yl)-4-methylpiperidin-4-ol | HCID 67029099 | — |
| 反応物 | 2-(4-Chlorophenyl)-3-((6-chloropyrazin-2-yl)methyl)imidazo[1,2-a]pyridine | HCID 86655124 | — |
| 生成物 | 2-((6-((2-(4-Chlorophenyl)imidazo[1,2-a]pyridin-3-yl)methyl)pyrazin-2-yl)(methyl)amino)ethanol | HCID 67027542 | — |
反応手順
The title compound was prepared according to the experimental for compound 187 from 2-(4-chlorophenyl)-3-((6-chloropyrazin-2-yl)methyl)imidazo[1,2-a]pyridine and 2-(methylamino)ethanol. M/e+ 394 for C21H21ClN5O (M+H)+; 1H-NMR (400 MHz, CDCl3) δ 8.06 (d, J=6.6 Hz, 1H), 7.89 (s, 1H), 7.78 (d, J=8.4 Hz, 2H), 7.70 (s, 1H), 7.60 (dd, J=8.4, 0.7 Hz, 1H), 7.40 (d, J=8.4 Hz, 2H), 7.17 (m, 1H), 6.77 (t, J=6.9 Hz, 1H), 4.34 (s, 2H), 3.64 (t, J=5.1 Hz, 2H), 3.54 (t, J=5.1 Hz, 2H), 3.05 (s, 3H) ppm.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08497278B2 |
| 出典データセット | uspto-grants-2013_07 |
| ORD ID | ord-a2851c04125e4ac689ea2699e2d956c6 |
| 出典メモ | uspto-grants-2013_07 |