Methylhydrazine → 2-(4-Chlorophenyl)-3-((6-(2-methylhydrazinyl)pyrazin-2-yl)methyl)imidazo[1,2-a]pyridine

HRID 455114ノート

反応式

HRID 455114 の反応式
ClC1C=CC2N(C(CNC3N=C(N4CCC(C)(O)CC4)C=CN=3)=C(C3C=CC=CC=3)N=2)C=1.[Cl:33][C:34]1[CH:39]=[CH:38][C:37]([C:40]2[N:41]=[C:42]3[CH:47]=[CH:46][CH:45]=[CH:44][N:43]3[C:48]=2[CH2:49][C:50]2[CH:55]=[N:54][CH:53]=[C:52](Cl)[N:51]=2)=[CH:36][CH:35]=1.[CH3:57][NH:58][NH2:59]>>[Cl:33][C:34]1[CH:39]=[CH:38][C:37]([C:40]2[N:41]=[C:42]3[CH:47]=[CH:46][CH:45]=[CH:44][N:43]3[C:48]=2[CH2:49][C:50]2[CH:55]=[N:54][CH:53]=[C:52]([NH:59][NH:58][CH3:57])[N:51]=2)=[CH:36][CH:35]=1

参加物

4

反応物 3

HCID 6061MethylhydrazineHCID 670290991-(2-((6-Chloro-2-phenylimidazo[1,2-a]pyridin-3-yl)methylamino)pyrimidin-4-yl)-4-methylpiperidin-4-olHCID 866551242-(4-Chlorophenyl)-3-((6-chloropyrazin-2-yl)methyl)imidazo[1,2-a]pyridine

生成物 1

HCID 670275572-(4-Chlorophenyl)-3-((6-(2-methylhydrazinyl)pyrazin-2-yl)methyl)imidazo[1,2-a]pyridine

実験手順

The title compound was prepared according to the experimental for compound 187 from 2-(4-chlorophenyl)-3-((6-chloropyrazin-2-yl)methyl)imidazo[1,2-a]pyridine and methylhydrazine. M/e+ 365 for C19H18ClN6 (M+H)+; 1H-NMR (400 MHz, CDCl3) δ 8.41 (s, 1H), 8.12 (d, J=6.9 Hz, 1H), 7.83 (d, J=8.4 Hz, 2H), 7.73 (s, 1H), 7.63 (d, J=9.1 Hz, 1H), 7.41 (d, J=8.4 Hz, 2H), 7.19 (m, 1H), 6.78 (t, J=6.9 Hz, 1H), 4.36 (s, 2H), 3.88 (bs, 2H), 3.18 (s, 3H) ppm.

出典と根拠

ORDレコード
ord-83efa8abc54a46d8ab4a2e508b40d52b
出典データセット
uspto-grants-2013_07
特許番号
US08497278B2

反応ノート

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