1H-1,2,4-Triazole, 1-methyl- → 6-fluoro-2-(4-fluorophenyl)-3-((1-methyl-1H-1,2,4-triazol-5-yl)methyl)imidazo[1,2-a]pyridine

HRID 455120

反応式

HRID 455120 の反応式
[F:1][C:2]1[CH:3]=[CH:4][C:5]2[N:6]([C:8]([CH2:18][C:19]3[N:20]([CH3:24])C=[CH:22][N:23]=3)=[C:9]([C:11]3[CH:16]=[CH:15][C:14]([F:17])=[CH:13][CH:12]=3)[N:10]=2)[CH:7]=1.FC1C=CC2[N:30](C(C=O)=C(C3C=CC(F)=CC=3)N=2)C=1.CN1C=NC=N1>>[F:1][C:2]1[CH:3]=[CH:4][C:5]2[N:6]([C:8]([CH2:18][C:19]3[N:20]([CH3:24])[N:30]=[CH:22][N:23]=3)=[C:9]([C:11]3[CH:12]=[CH:13][C:14]([F:17])=[CH:15][CH:16]=3)[N:10]=2)[CH:7]=1

参加物

4

反応物 3

HCID 224591H-1,2,4-Triazole, 1-methyl-HCID 670290646-fluoro-2-(4-fluorophenyl)-3-((1-methyl-1H-imidazol-2-yl)methyl)imidazo[1,2-a]pyridineHCID 730129166-Fluoro-2-(4-fluorophenyl)imidazo(1,2-a)pyridine-3-carbaldehyde

生成物 1

HCID 444733846-fluoro-2-(4-fluorophenyl)-3-((1-methyl-1H-1,2,4-triazol-5-yl)methyl)imidazo[1,2-a]pyridine収率 53%

実験手順

The title compound was prepared according to Method C and the experimentals described for compound 199 from 6-fluoro-2-(4-fluorophenyl)imidazo[1,2-a]pyridine-3-carbaldehyde and 1-methyl-1H-1,2,4-triazole. (0.19 g, 53% yield). M/e+ 326.2 for C17H14F2N5 (M+H)+; 1H-NMR (500 MHz, DMSO-d6, δ) 8.55 (dd, J=5.0, 2.0 Hz, 1H), 7.72-7.68 (m, 4H), 7.40-7.36 (m, 1H), 7.31-7.27 (m, 2H), 4.64 (s, 2H), 3.86 (s, 3H).

出典と根拠

ORDレコード
ord-9be643cd3ec9411da68e3cb202446076
出典データセット
uspto-grants-2013_07
特許番号
US08497278B2

関連ノート

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