2-Methyl-1,3,4-oxadiazole → 2-((6-Chloro-2-phenylimidazo[1,2-a]pyridin-3-yl)methyl)-5-methyl-1,3,4-oxadiazole

HRID 455124ノート

反応式

HRID 455124 の反応式
FC1C=CC2N(C(CC3N(C)C=CN=3)=C(C3C=CC(F)=CC=3)N=2)C=1.[Cl:25][C:26]1[CH:27]=[CH:28][C:29]2[N:30]([C:32]([CH:41]=O)=[C:33]([C:35]3[CH:40]=[CH:39][CH:38]=[CH:37][CH:36]=3)[N:34]=2)[CH:31]=1.[CH3:43][C:44]1[O:45][CH:46]=[N:47][N:48]=1>>[Cl:25][C:26]1[CH:27]=[CH:28][C:29]2[N:30]([C:32]([CH2:41][C:46]3[O:45][C:44]([CH3:43])=[N:48][N:47]=3)=[C:33]([C:35]3[CH:36]=[CH:37][CH:38]=[CH:39][CH:40]=3)[N:34]=2)[CH:31]=1

参加物

4

反応物 3

HCID 5584472-Methyl-1,3,4-oxadiazoleHCID 27577926-Chloro-2-phenylimidazo[1,2-a]pyridine-3-carbaldehydeHCID 670290646-fluoro-2-(4-fluorophenyl)-3-((1-methyl-1H-imidazol-2-yl)methyl)imidazo[1,2-a]pyridine

生成物 1

HCID 670291112-((6-Chloro-2-phenylimidazo[1,2-a]pyridin-3-yl)methyl)-5-methyl-1,3,4-oxadiazole

実験手順

The title compound was prepared according to Method C and the experimentals described for compound 199 from 6-chloro-2-phenylimidazo[1,2-a]pyridine-3-carbaldehyde and 2-methyl-1,3,4-oxadiazole. M/e+ 325 for C17H14ClN4O (M+H)+; 1H-NMR (400 MHz, CDCl3) δ 8.25 (d, J=1.4 Hz, 1H), 7.81 (d, J=8.4 Hz, 2H), 7.61 (d, J=9.5 Hz, 1H), 7.51 (d, J=8.4 Hz, 2H), 7.43 (d, J=7.3 Hz, 1H), 7.22 (dd, J=9.5, 1.8 Hz, 1H), 4.58 (s, 2H), 2.52 (s, 3H) ppm.

出典と根拠

ORDレコード
ord-2860dbaa1471475c910e5ae2c3f1e83d
出典データセット
uspto-grants-2013_07
特許番号
US08497278B2

反応ノート

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