Ammonia → 2-Amino-1-(4-chlorophenyl)-1-(4-iodophenyl)ethanol

HRID 455325

反応式

HRID 455325 の反応式
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2([C:11]3[CH:16]=[CH:15][C:14]([I:17])=[CH:13][CH:12]=3)[CH2:10][O:9]2)=[CH:4][CH:3]=1.CO.[NH3:20]>>[NH2:20][CH2:10][C:8]([C:5]1[CH:6]=[CH:7][C:2]([Cl:1])=[CH:3][CH:4]=1)([C:11]1[CH:16]=[CH:15][C:14]([I:17])=[CH:13][CH:12]=1)[OH:9]

参加物

4

反応物 3

HCID 222AmmoniaHCID 887MethanolHCID 593172172-(4-Chlorophenyl)-2-(4-iodophenyl)oxirane

生成物 1

HCID 250132692-Amino-1-(4-chlorophenyl)-1-(4-iodophenyl)ethanol

反応条件

温度
130 °C

実験手順

2-(4-Chloro-phenyl)-2-(4-iodo-phenyl)-oxirane (500 mg, 1.40 mmol) was dissolved in 2M NH3 in methanol (5 ml, 10.0 mmol) and the solution was heated in a microwave at 130° C. for 60 minutes. Upon cooling, the solvent was removed in vacuo to furnish the desired product. Three identical reactions were carried out and afforded 1.55 g (98%) of the product 2-amino-1-(4-chloro-phenyl)-1-[4-iodo-phenyl]-ethanol. The crude product was pure and was used in the next step without purification.

後処理

  1. temperatureUpon cooling
  2. customthe solvent was removed in vacuo

出典と根拠

ORDレコード
ord-d87d8571873a4d2d9b7ef0414d3f972e
出典データセット
uspto-grants-2013_07
特許番号
US08497294B2

関連ノート

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