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3-Amino-4-methoxybenzoic acid → (3-Amino-4-methoxy-phenyl)-(cis-2,3,4a,5,6,10b-hexahydro-1H-benzo[f]quinolin-4-yl)-methanone
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 3-Amino-4-methoxybenzoic acid | HCID 17823 | — |
| 反応物 | Methanaminium, N-((dimethylamino)(3H-1,2,3-triazolo(4,5-b)pyridin-3-yloxy)methylene)-N-methyl-, hexafluorophosphate(1-) (1:1) | HCID 9886157 | — |
| 反応物 | (4aS,10bR)-1,2,3,4,4a,5,6,10b-Octahydrobenzo[f]quinoline | HCID 12327022 | — |
| 生成物 | (3-Amino-4-methoxy-phenyl)-(cis-2,3,4a,5,6,10b-hexahydro-1H-benzo[f]quinolin-4-yl)-methanone | HCID 86654111 | 63% |
反応手順
The title compound is prepared from 3-amino-4-methoxy-benzoic acid and cis-1,2,3,4,4a,5,6,10b-octahydro-benzo[f]quinoline following a procedure analogous to that described in Example 1 [2-(7-aza-1H-benzotriazol-1-yl)-1,1,3,3-tetramethyluronium hexa-fluorophosphate is used]. Yield: 63% of theory; LC (method 4): tR=1.79 min; Mass spectrum (ESI+): m/z=337 [M+H]+.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08497281B2 |
| 出典データセット | uspto-grants-2013_07 |
| ORD ID | ord-60668a75d39c4bd58d212974dcc51239 |
| 出典メモ | uspto-grants-2013_07 |