Potassium Cyanide → 2-(2,3-Dihydro-1,4-benzodioxin-2-yl)acetonitrile

HRID 455535

反応式

HRID 455535 の反応式
[C-:1]#[N:2].[K+].Br[CH2:5][CH:6]1[O:11][C:10]2[CH:12]=[CH:13][CH:14]=[CH:15][C:9]=2[O:8][CH2:7]1>CS(C)=O.O>[C:1]([CH2:5][CH:6]1[O:11][C:10]2[CH:12]=[CH:13][CH:14]=[CH:15][C:9]=2[O:8][CH2:7]1)#[N:2]

参加物

5

反応物 2

HCID 9032Potassium CyanideHCID 983332-Bromomethyl-1,4-benzodioxane

生成物 1

HCID 2675312-(2,3-Dihydro-1,4-benzodioxin-2-yl)acetonitrile

試薬・触媒・溶媒 2

HCID 679Dimethyl Sulfoxide溶媒HCID 962Water溶媒

実験手順

Potassium cyanide (2.05 g, 31.5 mmol) was added to 2-bromomethyl-(2,3 dihydrobenzo[1,4]dioxine) (6.87 g, 30 mmol) in DMSO (90 mL) and stirred at ambient temperature for 20 h. The reaction mixture was then diluted with water (250 mL) and extracted twice with diethyl ether. The diethyl ether was washed with water, then washed twice with brine, dried (Na2SO4) and evaporated in vacuo to yield 2-cyanomethyl-(2,3 dihydrobenzo[1,4]dioxine) as a white solid.

後処理

  1. extractionextracted twice with diethyl ether
  2. washThe diethyl ether was washed with water
  3. washwashed twice with brine
  4. dry with materialdried (Na2SO4)
  5. customevaporated in vacuo

出典と根拠

ORDレコード
ord-21f41a6878e248b4a2132810be251508
出典データセット
uspto-grants-2013_07
特許番号
US08497298B2

関連ノート

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