Epichlorohydrin → 1-(2,3-Epoxypropoxy)-4-(2-hydroxyethoxy)benzene

HRID 4557

反応式

HRID 4557 の反応式
[OH:1][CH2:2][CH2:3][O:4][C:5]1[CH:10]=[CH:9][C:8]([OH:11])=[CH:7][CH:6]=1.[CH2:12]([CH:14]1[O:16][CH2:15]1)Cl.C(=O)([O-])[O-].[K+].[K+]>>[O:16]1[CH2:15][CH:14]1[CH2:12][O:11][C:8]1[CH:7]=[CH:6][C:5]([O:4][CH2:3][CH2:2][OH:1])=[CH:10][CH:9]=1

参加物

4

反応物 3

HCID 7835EpichlorohydrinHCID 11430Potassium CarbonateHCID 98340144-(2-Hydroxyethoxy)phenol

生成物 1

HCID 201513091-(2,3-Epoxypropoxy)-4-(2-hydroxyethoxy)benzene

実験手順

With stirring, 13 g of crude 4-(2-hydroxyethoxy)phenol, 35 m of epichlorohydrin and 23.5 g of potassium carbonate are heated for 11/2 hours to reflux temperature. The reaction mixture is filtered and the filtrate is concentrated by evaporation under reduced pressure. The residual oil gradually congeals to a crystalline solid, which is recrystallised from isopropanol, affording 1-(2,3-epoxypropoxy)-4-(2-hydroxyethoxy)benzene with a melting point of 65°-67° C. Working up of the mother liquor yields further crystalline product.

後処理

  1. temperatureto reflux temperature
  2. filtrationThe reaction mixture is filtered
  3. concentrationthe filtrate is concentrated by evaporation under reduced pressure
  4. customis recrystallised from isopropanol

出典と根拠

ORDレコード
ord-74326da63a1b43b7b1f17eec13973a19
出典データセット
uspto-grants-1988_02
特許番号
US04727067

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