Epichlorohydrin → 1-(2,3-Epoxypropoxy)-4-(2-hydroxyethoxy)benzene
反応式
[OH:1][CH2:2][CH2:3][O:4][C:5]1[CH:10]=[CH:9][C:8]([OH:11])=[CH:7][CH:6]=1.[CH2:12]([CH:14]1[O:16][CH2:15]1)Cl.C(=O)([O-])[O-].[K+].[K+]>>[O:16]1[CH2:15][CH:14]1[CH2:12][O:11][C:8]1[CH:7]=[CH:6][C:5]([O:4][CH2:3][CH2:2][OH:1])=[CH:10][CH:9]=1参加物
4
実験手順
With stirring, 13 g of crude 4-(2-hydroxyethoxy)phenol, 35 m of epichlorohydrin and 23.5 g of potassium carbonate are heated for 11/2 hours to reflux temperature. The reaction mixture is filtered and the filtrate is concentrated by evaporation under reduced pressure. The residual oil gradually congeals to a crystalline solid, which is recrystallised from isopropanol, affording 1-(2,3-epoxypropoxy)-4-(2-hydroxyethoxy)benzene with a melting point of 65°-67° C. Working up of the mother liquor yields further crystalline product.
後処理
- temperatureto reflux temperature
- filtrationThe reaction mixture is filtered
- concentrationthe filtrate is concentrated by evaporation under reduced pressure
- customis recrystallised from isopropanol
出典と根拠
- ORDレコード
- ord-74326da63a1b43b7b1f17eec13973a19
- 出典データセット
- uspto-grants-1988_02
- 特許番号
- US04727067
反応ノート
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