関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Pyridine | HCID 1049 | — |
| 反応物 | Tetrahydrofuran | HCID 8028 | — |
| 反応物 | 4-Bromobenzoyl chloride | HCID 68515 | — |
| 反応物 | Methyl 3-(methylamino)but-2-enoate | HCID 2734182 | — |
| 生成物 | Methyl acetyl(p-bromobenzoyl)acetate | HCID 603116 | — |
反応手順
To 3-methylamino-but-2-enoic acid methyl ester (5.0 g, 39.1 mmol) in THF (100 mL) was added pyridine (3.7 mL, 47 mmol). The mixture was cooled to 0° C., and 4-bromobenzoyl chloride (8.55 g, 39.1 mmol) in THF (30 mL) was added dropwise over 2 minutes. The reaction was warmed to room temperature over 1 hour and stirred overnight. Aqueous workup provided the title compound.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US08541587B2 |
|---|
| 出典データセット | uspto-grants-2013_09 |
|---|
| ORD ID | ord-34df59fc39704324b6849d543dc6d57b |
|---|
| 出典メモ | uspto-grants-2013_09 |
|---|
