関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Hydroxyamine hydrochloride | HCID 443297 | — |
| 反応物 | Methyl acetyl(p-bromobenzoyl)acetate | HCID 603116 | — |
| 溶媒 | Acetic Acid | HCID 176 | — |
| 生成物 | Methyl 5-(4-bromophenyl)-3-methylisoxazole-4-carboxylate | HCID 56604575 | — |
反応手順
To a mixture of 2-(4-bromo-benzoyl)-3-oxo-butyric acid methyl ester (11 g, 39 mmol) in acetic acid (50 mL) was added hydroxylamine hydrochloride (2.66 g, 39 mmol), and the reaction was stirred at 115° C. for 1 hour. After cooling, aqueous workup provided the title compound, which was used directly in the hydrolysis step.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US08541587B2 |
|---|
| 出典データセット | uspto-grants-2013_09 |
|---|
| ORD ID | ord-279da9bd723a40a8a2cec518d7839aad |
|---|
| 出典メモ | uspto-grants-2013_09 |
|---|
