HCID 136391012、化合物 → Udenafil
反応式
[CH3:1][CH2:2][CH2:3][C:4]1[C:5]2[N:14]=[C:13]([C:15]3[CH:16]=[C:17]([S:25]([NH:28][CH2:29][CH2:30][CH:31]4[N:35]([CH3:36])[CH2:34][CH2:33][CH2:32]4)(=[O:27])=[O:26])[CH:18]=[CH:19][C:20]=3[O:21][CH2:22][CH2:23][CH3:24])[NH:12][C:10](=[O:11])[C:6]=2[N:7]([CH3:9])[N:8]=1.Cl>C(O)C>[CH3:1][CH2:2][CH2:3][C:4]1[C:5]2[N:14]=[C:13]([C:15]3[CH:16]=[C:17]([S:25]([NH:28][CH2:29][CH2:30][CH:31]4[N:35]([CH3:36])[CH2:34][CH2:33][CH2:32]4)(=[O:27])=[O:26])[CH:18]=[CH:19][C:20]=3[O:21][CH2:22][CH2:23][CH3:24])[NH:12][C:10](=[O:11])[C:6]=2[N:7]([CH3:9])[N:8]=1参加物
3
反応条件
- 温度
- 50 °C
実験手順
20 g of sodium CMC is dissolved in water to form a 5% viscous aqueous solution (40 ml). Udenafil HCl (20.6 g) is added to the solution and the mixture is stirred at 50° C. for 1 hr to obtain a white precipitate. The solution is poured out then the ethanol (100 ml) is added for dehydration. Ethanol (100 ml) is added additionally to wash out the unreacted Udenafil, over night and warmed in water bath at 50° C. and cooled at room temperature over night to obtain the precipitate of Udenail-CMC complex (32.8 g).