Pipemidic Acid → 2-(4-{[(3-Methylphenyl)amino]carbonothioyl}-1-piperazinyl)-8-ethyl-5-oxo-5,8-dihydropyrido[2,3-d]pyrimidine-6-carboxylic Acid
反応式
[CH3:1][CH2:2][N:3]1[C:9]2[N:10]=[C:11]([N:14]3[CH2:19][CH2:18][NH:17][CH2:16][CH2:15]3)[N:12]=[CH:13][C:8]=2[C:6](=[O:7])[C:5]([C:20]([OH:22])=[O:21])=[CH:4]1.[C:23]1([CH3:32])[CH:28]=[CH:27][CH:26]=[C:25]([N:29]=[C:30]=[S:31])[CH:24]=1>>[CH3:32][C:23]1[CH:24]=[C:25]([NH:29][C:30]([N:17]2[CH2:18][CH2:19][N:14]([C:11]3[N:12]=[CH:13][C:8]4[C:6](=[O:7])[C:5]([C:20]([OH:22])=[O:21])=[CH:4][N:3]([CH2:2][CH3:1])[C:9]=4[N:10]=3)[CH2:15][CH2:16]2)=[S:31])[CH:26]=[CH:27][CH:28]=1参加物
3
実験手順
Pipemidic acid (54 mg, 0.177 mmol) and m-tolylisothiocyanate (20 μL, 0.148 mmol) were used. Purification on silica yielded compound 13 in Table 1, below (67 mg, 100%). 1H NMR (300 MHz, CDCl3) δ 9.32 (s, 1H), 8.68 (s, 1H), 7.34-7.32 (m, 1H), 7.05-6.94 (m, 3H), 4.33 (q, J=7.10 Hz, 2H), 4.24-3.87 (m, 8H), 2.35 (s, 3H), 1.49 (t, J=7.19 Hz, 3H) ppm.
後処理
- customPurification on silica yielded compound 13 in Table 1