Pipemidic Acid → 2-(4-{[(3-Fluorophenyl)amino]carbonothioyl}-1-piperazinyl)-8-ethyl-5-oxo-5,8-dihydropyrido[2,3-d]pyrimidine-6-carboxylic Acid

関与物質

反応手順

Pipemidic acid (25 mg, 0.0824 mmol) and 3-fluorophenyl isothiocyanate (9.9 μL, 0.0824 mmol) were used. Purification on silica yielded compound 25 in Table 1, below (22 mg, 59%). 1H NMR (300 MHz, CDCl3) δ 9.32 (s, 1H), 8.66 (s, 1H), 7.41 (s, 1H), 7.37-7.27 (m, 1H), 6.96 (t, J=7.39, 2H), 6.88 (t, J=7.67 Hz, 1H), 4.38-4.27 (m, 2H), 4.27-3.91 (m, 8H), 1.54-1.43 (m, 3H) ppm.

情報源と証拠