化工社化工社 化学情報印刷レポート · 研究参考用
1,2-Dibromoethane → 1-(4-Bromophenyl)Cyclopropanecarbonitrile
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 1,2-Dibromoethane | HCID 7839 | — |
| 反応物 | Potassium Hydroxide | HCID 14797 | — |
| 反応物 | Benzeneacetonitrile, 4-bromo- | HCID 27914 | — |
| 触媒 | Tetrabutylammonium Bromide | HCID 74236 | — |
| 溶媒 | Water | HCID 962 | — |
| 溶媒 | Toluene | HCID 1140 | — |
| 生成物 | 1-(4-Bromophenyl)Cyclopropanecarbonitrile | HCID 2795273 | — |
反応手順
Potassium hydroxide (14.3 g, 255 mmol) was dissolved in H2O (5 mL) and toluene (40 mL). 4-Bromophenylacetonitrile (5.0 g, 25.5 mmol) and tetrabutylammonium bromide (0.41 g, 1.3 mmol) was added, followed by 1,2-dibromoethane (3.25 mL, 38 mmol) dropwise over 10 minutes. The reaction was stirred at room temperature for 2 hours and then worked-up to give the title compound.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08541587B2 |
| 出典データセット | uspto-grants-2013_09 |
| ORD ID | ord-e407ecf3ec3f4db980e6cba4bd4ea977 |
| 出典メモ | uspto-grants-2013_09 |