Pipemidic Acid → 2-(4-{[(4-Trifluoromethylphenyl)amino]carbonothioyl}-1-piperazinyl)-8-ethyl-5-oxo-5,8-dihydropyrido[2,3-d]pyrimidine-6-carboxylic Acid

関与物質

反応手順

Pipemidic acid (30 mg, 0.0989 mmol) and 4-trifluoromethylphenyl isothiocyanate (16.7 mg, 0.0824 mmol) were used. Purification on silica yielded compound 31 in Table 1, below (31 mg, 77%). 1H NMR (300 MHz, CDCl3) δ 9.34 (s, 1H), 8.69 (s, 1H), 7.65-7.57 (m, 2H), 7.51 (s, 1H), 7.37-7.31 (m, 2H), 4.34 (q, J=6.80 Hz, 2H), 4.27-3.97 (m, 8H), 1.49 (t, J=7.25, 7.25 Hz, 3H) ppm.

情報源と証拠