反応式
[Cl:1][C:2]1[N:3]=[N:4][C:5]([NH:8][NH2:9])=[CH:6][CH:7]=1.[N:10]1[C:19]2[C:14](=[CH:15][C:16]([CH2:20][C:21](O)=[O:22])=[CH:17][CH:18]=2)[CH:13]=[CH:12][CH:11]=1.C1CCC(N=C=NC2CCCCC2)CC1.C1(NC(NC2CCCCC2)=O)CCCCC1>C(Cl)Cl>[Cl:1][C:2]1[N:3]=[N:4][C:5]([NH:8][NH:9][C:21](=[O:22])[CH2:20][C:16]2[CH:15]=[C:14]3[C:19](=[CH:18][CH:17]=2)[N:10]=[CH:11][CH:12]=[CH:13]3)=[CH:6][CH:7]=1参加物
6
実験手順
To a suspension of 3-chloro-6-hydrazinylpyridazine (3 g, 20.75 mmol) and 2-(quinolin-6-yl)acetic acid (4.27 g, 22.83 mmol) in 200 ml DCM was added DCC (5.14 g, 24.90 mmol). The solution was stirred at room temperature for overweekend. The title compound as a white solid containing dicyclohexyl urea was filtered and used in the next step without further purification (8 g, 100%). LCMS (method A): [MH]+=314.1, tR=2.85 min.
出典と根拠
- ORDレコード
- ord-95c9a771fe5241dcb472b32e08127bc6
- 出典データセット
- uspto-grants-2013_07
- 特許番号
- US08497368B2
関連ノート
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