反応式
[CH2:1]([NH:8][C:9]([NH:11][NH2:12])=[S:10])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[F:13][C:14]1[CH:23]=[C:22]2[C:17]([CH:18]=[CH:19][CH:20]=[N:21]2)=[CH:16][C:15]=1[CH2:24][C:25]1[N:29]2[N:30]=[C:31]([C:34](=O)[CH3:35])[CH:32]=[CH:33][C:28]2=[N:27][CH:26]=1>>[CH2:1]([NH:8][C:9]([NH:11]/[N:12]=[C:34](/[C:31]1[CH:32]=[CH:33][C:28]2[N:29]([C:25]([CH2:24][C:15]3[CH:16]=[C:17]4[C:22](=[CH:23][C:14]=3[F:13])[N:21]=[CH:20][CH:19]=[CH:18]4)=[CH:26][N:27]=2)[N:30]=1)\[CH3:35])=[S:10])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1参加物
3
実験手順
The title compound was prepared from N-benzylhydrazine carbothioamide and 1-[3-(7-fluoro-quinolin-6-ylmethyl)-imidazo[1,2-b]pyridazin-6-yl]-ethanone in analogy to the synthesis of example 1 in 80% yield. 1H-NMR (400 MHz, DMSO-d6) δ ppm 10.58 (s, 1H), 9.30 (t, 1H), 8.86 (dd, 1H), 8.30 (m, 2H), 8.05 (d, 1H), 7.95 (d, 1H), 7.77 (d, 1H), 7.69 (s, 1H), 7.47 (q, 1H), 7.32 (m, 4H), 7.23 (m, 1H), 4.89 (d, 2H), 4.58 (s, 2H), 2.39 (s, 3H). LCMS (method C): [MH]+=484, tR=4.18 min.
出典と根拠
- ORDレコード
- ord-70e0ac505cc44e77ab5dc6d678e62eaa
- 出典データセット
- uspto-grants-2013_07
- 特許番号
- US08497368B2
関連ノート
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