化工社化工社 化学情報印刷レポート · 研究参考用
Stannane, tributyl(1-ethoxyethenyl)- → 1-(3-(Quinolin-6-ylmethyl)-[1,2,4]triazolo[4,3-b]pyridazin-6-yl)ethanone
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Stannane, tributyl(1-ethoxyethenyl)- | HCID 619414 | — |
| 反応物 | 6-((6-Chloro-[1,2,4]triazolo[4,3-b]pyridazin-3-yl)methyl)quinoline | HCID 24968367 | — |
| 反応物 | 1-(3-(1-(4,6-Difluoro-1-methyl-1H-indazol-5-yl)ethyl)imidazo[1,2-b]pyridazin-6-yl)ethanone | HCID 58190580 | — |
| 触媒 | Tetrakis(triphenylphosphine)palladium | HCID 11979704 | — |
| 溶媒 | Dimethylformamide | HCID 6228 | — |
| 生成物 | 1-(3-(Quinolin-6-ylmethyl)-[1,2,4]triazolo[4,3-b]pyridazin-6-yl)ethanone | HCID 58190461 | 51.4% |
反応手順
The title compound as a light yellow solid (500 mg, 51%) was synthesized from 6-((6-chloro-[1,2,4]triazolo[4,3-b]pyridazin-3-yl)methyl)quinoline (950 mg, 3.21 mmol), tributyl(1-ethoxy-vinyl)stannane (1.142 ml, 3.37 mmol) and tetrakis-(triphenylphosphine)-palladium (186 mg, 0.161 mmol) in DMF using the same procedure as described in the synthesis of compound 31.4. LCMS (method B): [MH]+=304.1, tR=1.71 min.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08497368B2 |
| 出典データセット | uspto-grants-2013_07 |
| ORD ID | ord-972f8da95d734aa6b0c1908c32ba9348 |
| 出典メモ | uspto-grants-2013_07 |