3-Amino-2-oxazolidinone → 3-[(E)-1-[3-[(5,7-difluoroquinolin-6-yl)methyl]-[1,2,4]triazolo[4,3-b]pyridazin-6-yl]ethylideneamino]-1,3-oxazolidin-2-one

HRID 456111

反応式

HRID 456111 の反応式
[NH2:1][N:2]1[CH2:6][CH2:5][O:4][C:3]1=[O:7].[F:8][C:9]1[C:18]([CH2:19][C:20]2[N:24]3[N:25]=[C:26]([C:29](=O)[CH3:30])[CH:27]=[CH:28][C:23]3=[N:22][N:21]=2)=[C:17]([F:32])[CH:16]=[C:15]2[C:10]=1[CH:11]=[CH:12][CH:13]=[N:14]2>>[F:8][C:9]1[C:18]([CH2:19][C:20]2[N:24]3[N:25]=[C:26](/[C:29](=[N:1]/[N:2]4[CH2:6][CH2:5][O:4][C:3]4=[O:7])/[CH3:30])[CH:27]=[CH:28][C:23]3=[N:22][N:21]=2)=[C:17]([F:32])[CH:16]=[C:15]2[C:10]=1[CH:11]=[CH:12][CH:13]=[N:14]2

参加物

3

反応物 2

HCID 657253-Amino-2-oxazolidinoneHCID 581905331-(3-((5,7-Difluoroquinolin-6-yl)methyl)-[1,2,4]triazolo[4,3-b]pyridazin-6-yl)ethanone

生成物 1

HCID 509163503-[(E)-1-[3-[(5,7-difluoroquinolin-6-yl)methyl]-[1,2,4]triazolo[4,3-b]pyridazin-6-yl]ethylideneamino]-1,3-oxazolidin-2-one収率 86%

実験手順

The title compound was prepared from 3-aminooxazolidin-2-one and 1-(3-((5,7-difluoroquinolin-6-yl)methyl)-[1,2,4]triazolo[4,3-b]pyridazin-6-yl)ethanone in 86% yield as white solid using the same procedure as described in the synthesis of example 40. 1H-NMR (400 MHz, DMSO-d6) δ ppm 9.00 (d, 1H), 8.50 (d, 1H), 8.33 (d, 1H); 7.87 (d, 1H), 7.75 (d, 1H), 7.63 (dd, 1H), 4.81 (s, 2H), 4.49 (t, 2H), 4.05 (t, 2H), 2.33 (s, 3H). LCMS (method A): [MH]+=424, tR=4.54 min.

後処理

  1. customas described in the synthesis of example 40

出典と根拠

ORDレコード
ord-8dcb8f2c2aeb4651875ea5a2ea5791df
出典データセット
uspto-grants-2013_07
特許番号
US08497368B2

関連ノート

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