1-Ethylhydrazinecarboxamide → 1-ethyl-1-[(E)-1-[3-(quinolin-6-ylmethyl)triazolo[4,5-b]pyrazin-5-yl]ethylideneamino]urea
反応式
[N:1]1[C:10]2[C:5](=[CH:6][C:7]([CH2:11][N:12]3[C:16]4=[N:17][C:18]([C:21](=O)[CH3:22])=[CH:19][N:20]=[C:15]4[N:14]=[N:13]3)=[CH:8][CH:9]=2)[CH:4]=[CH:3][CH:2]=1.[CH2:24]([N:26]([C:28]([NH2:30])=[O:29])[NH2:27])[CH3:25]>>[CH2:24]([N:26]([C:28]([NH2:30])=[O:29])/[N:27]=[C:21](/[C:18]1[N:17]=[C:16]2[N:12]([CH2:11][C:7]3[CH:6]=[C:5]4[C:10](=[CH:9][CH:8]=3)[N:1]=[CH:2][CH:3]=[CH:4]4)[N:13]=[N:14][C:15]2=[N:20][CH:19]=1)\[CH3:22])[CH3:25]参加物
3
実験手順
The title compound was prepared in 57% yield as a white solid in analogy to the synthesis of example 52 from 1-(1-(quinolin-6-ylmethyl)-1H-[1,2,3]triazolo[4,5-b]pyrazin-6-yl)ethanone and 1-ethylhydrazine-carboxamide. 1H-NMR (400 MHz, DMSO-d6) δ ppm 9.61 (s, 1H), 8.89 (d, 1H), 8.36 (d, 1H), 8.03 (s, 1H), 8.00 (d, 1H), 7.83 (d, 1H), 7.53 (m, 1H), 6.61 (d, 2H), 6.22 (s, 2H), 3.80 (q, 2H), 2.42 (s, 3H), 1.07 (t, 3H). LCMS (method B): [MH]+=390, tR=1.98 min.
出典と根拠
- ORDレコード
- ord-29b5665190df4c4a83b53568c207f034
- 出典データセット
- uspto-grants-2013_07
- 特許番号
- US08497368B2
反応ノート
読み込み中…