6-[6-(1-Ethoxy-vinyl)[1,2,3]triazolo[4,5-b]pyrazin-1-ylmethyl]-quinoline → 6-(1-(6-(1-Ethoxyvinyl)-1H-[1,2,3]triazolo[4,5-b]pyrazin-1-yl)ethyl)-7-fluoroquinoline

HRID 456143

反応式

HRID 456143 の反応式
[CH2:1]([O:3][C:4](C1N=C2N(CC3C=C4C(=CC=3)N=CC=C4)N=NC2=NC=1)=[CH2:5])[CH3:2].Br[C:27]1[N:32]=[C:31]2[N:33]([CH:36]([C:38]3[CH:39]=[C:40]4[C:45](=[CH:46][C:47]=3[F:48])[N:44]=[CH:43][CH:42]=[CH:41]4)[CH3:37])[N:34]=[N:35][C:30]2=[N:29][CH:28]=1>>[CH2:4]([O:3][C:1]([C:27]1[N:32]=[C:31]2[N:33]([CH:36]([C:38]3[CH:39]=[C:40]4[C:45](=[CH:46][C:47]=3[F:48])[N:44]=[CH:43][CH:42]=[CH:41]4)[CH3:37])[N:34]=[N:35][C:30]2=[N:29][CH:28]=1)=[CH2:2])[CH3:5]

参加物

3

反応物 2

HCID 248519576-[6-(1-Ethoxy-vinyl)[1,2,3]triazolo[4,5-b]pyrazin-1-ylmethyl]-quinolineHCID 866660826-(1-(6-Bromo-1H-[1,2,3]triazolo[4,5-b]pyrazin-1-yl)ethyl)-7-fluoroquinoline

生成物 1

HCID 669272076-(1-(6-(1-Ethoxyvinyl)-1H-[1,2,3]triazolo[4,5-b]pyrazin-1-yl)ethyl)-7-fluoroquinoline

実験手順

The title compound was prepared in analogy to the synthesis of compound 52.3 from 6-(1-(6-bromo-1H-[1,2,3]triazolo[4,5-b]pyrazin-1-yl)ethyl)-7-fluoroquinoline. 1H-NMR (400 MHz, CDCl3) δ ppm 9.17 (9.17 (s, 1H), 8.90 (m, 1H), 8.10 (d, 1H), 7.89 (d, 1H), 7.78 (d, 1H), 7.39 (dd, 1H), 6.82 (q, 1H), 5.56 (d, 1H), 4.56 (d, 1H), 4.04 (q, 2H), 2.30 (d, 3H), 1.48 (t, 3H). LCMS (method B): [MH]+=365, tR=2.55 min.

出典と根拠

ORDレコード
ord-d37acd31ff2849e687719bb64c565e21
出典データセット
uspto-grants-2013_07
特許番号
US08497368B2

関連ノート

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