Methyl 2-(4-methoxy-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-YL)phenyl)acetate → [4'-Fluoro-6-methoxy-2'-((4S,5R)-4-methyl-2-oxo-5-phenyl-oxazolidin-3-ylmethyl)-biphenyl-3-yl]-acetic acid methyl ester

HRID 456200

反応式

HRID 456200 の反応式
Br[C:2]1[CH:21]=[CH:20][C:19]([F:22])=[CH:18][C:3]=1[CH2:4][N:5]1[C@@H:9]([CH3:10])[C@@H:8]([C:11]2[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=2)[O:7][C:6]1=[O:17].[CH3:23][O:24][C:25](=[O:44])[CH2:26][C:27]1[CH:32]=[CH:31][C:30]([O:33][CH3:34])=[C:29](B2OC(C)(C)C(C)(C)O2)[CH:28]=1>>[CH3:23][O:24][C:25](=[O:44])[CH2:26][C:27]1[CH:28]=[C:29]([C:2]2[CH:21]=[CH:20][C:19]([F:22])=[CH:18][C:3]=2[CH2:4][N:5]2[C@@H:9]([CH3:10])[C@@H:8]([C:11]3[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=3)[O:7][C:6]2=[O:17])[C:30]([O:33][CH3:34])=[CH:31][CH:32]=1

参加物

3

反応物 2

HCID 57576289Methyl 2-(4-methoxy-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-YL)phenyl)acetateHCID 58120056(4S,5R)-3-(2-Bromo-5-fluoro-benzyl)-4-methyl-5-phenyl-oxazolidin-2-one

生成物 1

HCID 58120044[4'-Fluoro-6-methoxy-2'-((4S,5R)-4-methyl-2-oxo-5-phenyl-oxazolidin-3-ylmethyl)-biphenyl-3-yl]-acetic acid methyl ester

実験手順

Prepared according to the procedure described in Example 1, Step 4, using the following starting materials: (4S,5R)-3-(2-bromo-5-fluoro-benzyl)-4-methyl-5-phenyl-oxazolidin-2-one and [4-methoxy-3-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-phenyl]-acetic acid methyl ester.

後処理

  1. customPrepared

出典と根拠

ORDレコード
ord-607fd1383d994e33897cd11ff92f6378
出典データセット
uspto-grants-2013_07
特許番号
US08497381B2

関連ノート

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