化工社化工社 化学情報印刷レポート · 研究参考用
2-Indanmethanol → N-[4-(2,3-Dihydro-1H-inden-2-ylmethoxy)benzoyl]glycine
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 2-Indanmethanol | HCID 228873 | — |
| 反応物 | N-(4-Hydroxybenzoyl)glycine tert-butyl ester | HCID 10682169 | — |
| 生成物 | N-[4-(2,3-Dihydro-1H-inden-2-ylmethoxy)benzoyl]glycine | HCID 66812427 | 85% |
反応手順
The same reaction as in Example 1 (1b) was conducted using N-(4-hydroxybenzoyl)glycine tert-butyl ester (250 mg, 0.995 mmol) prepared in Example 1 (1a) and 2,3-dihydro-1H-inden-2-ylmethanol (which is the compound disclosed in J. Med. Chem., (1989), 32, 1326-1334, 165 mg, 1.11 mmol) to give 263 mg of the title compound (colorless crystalline solid, yield: 85%).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08497397B2 |
| 出典データセット | uspto-grants-2013_07 |
| ORD ID | ord-c8d0a65cc70e4dbea6294969b13f136a |
| 出典メモ | uspto-grants-2013_07 |