2-(2-Fluorophenyl)ethan-1-ol → N-{4-[2-(2-Fluorophenyl)ethoxy]benzoyl}glycine

反応式

C([O:5][C:6](=[O:18])[CH2:7][NH:8][C:9](=[O:17])[C:10]1[CH:15]=[CH:14][C:13]([OH:16])=[CH:12][CH:11]=1)(C)(C)C.[F:19][C:20]1[CH:25]=[CH:24][CH:23]=[CH:22][C:21]=1[CH2:26][CH2:27]O>>[F:19][C:20]1[CH:25]=[CH:24][CH:23]=[CH:22][C:21]=1[CH2:26][CH2:27][O:16][C:13]1[CH:12]=[CH:11][C:10]([C:9]([NH:8][CH2:7][C:6]([OH:5])=[O:18])=[O:17])=[CH:15][CH:14]=1

参加物

反応物 2

HCID 27332962-(2-Fluorophenyl)ethan-1-ol

HCID 10682169N-(4-Hydroxybenzoyl)glycine tert-butyl ester

生成物 1

HCID 66811873N-{4-[2-(2-Fluorophenyl)ethoxy]benzoyl}glycine収率 73.4%

実験手順

The same reaction as in Example 1 (1b) was conducted using N-(4-hydroxybenzoyl)glycine tert-butyl ester (231 mg, 0.919 mmol) prepared in Example 1 (1a) and 2-(2-fluorophenyl)ethanol (137 μL, 1.02 mmol) to give 214 mg of the title compound (white powder, yield: 73%).

出典と根拠

ORDレコード: ord-7e1957fc67d34f99b2c613230d83fceb
出典データセット: uspto-grants-2013_07
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US08497397B2

反応ノート

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