3'-Bromoacetophenone → 2-Bromo-1-(3-bromophenyl)ethan-1-one

温度

60 °C

Into a 500-mL 3-necked round-bottom flask, was placed a solution of 1-(3-bromophenyl)ethanone (40 g, 202.02 mmol, 1.00 equiv) in acetic acid (200 mL). This was followed by the addition of a solution of Br2 (32 g, 200.00 mmol) in acetic acid (50 mL) dropwise with stirring at 60° C. The resulting solution was stirred for 3 h at 60° C. in an oil bath. The resulting mixture was concentrated under vacuum. The crude product was re-crystallized from petroleum ether:ethyl acetate in the ratio of 8:1. This resulted in 24 g (43%) of 2-bromo-1-(3-bromophenyl)ethanone as a yellow solid.

1. customInto a 500-mL 3-necked round-bottom flask, was placed
2. stirringThe resulting solution was stirred for 3 h at 60° C. in an oil bath
3. concentrationThe resulting mixture was concentrated under vacuum
4. customThe crude product was re-crystallized from petroleum ether
5. customThis resulted in 24 g (43%) of 2-bromo-1-(3-bromophenyl)ethanone as a yellow solid

ORDレコード

ord-543de9c65f6e42f7ac21c2a1f2b683ee

出典データセット

uspto-grants-2013_09

DOI

10.6084/m9.figshare.5104873.v1

特許番号

US08541448B2