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Acetate → 4-(4-(2-Hydroxyphenyl)thiophenyl)butyric acid
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Acetate | HCID 175 | — |
| 反応物 | Potassium Carbonate | HCID 11430 | — |
| 反応物 | Phenol, o-mercapto-(6CI,7CI,8CI) | HCID 70718 | — |
| 反応物 | 4-(p-Iodophenyl)butyric acid | HCID 4645427 | — |
| 溶媒 | Dimethylformamide | HCID 6228 | — |
| 生成物 | 4-(4-(2-Hydroxyphenyl)thiophenyl)butyric acid | HCID 68494380 | — |
反応手順
A solution of 4-(4-iodophenyl)butyric acid (0.86M) and dimethylformamide was treated with 2 eq of potassium carbonate, 1.5 eq of 2-hydroxythiophenol and a catalytic amount of cuperic acetate (0.01 eq). The reaction mixture was refluxed for 18 hr, cooled to 25 C., acidified with aqueous acid and extracted with ethyl acetate. The organic phase was concentrated. The residue was purified by flash chromatography using ethyl acetate/hexane as eluant to give 4-(4-(2-hydroxyphenyl)thiophenyl)butyric acid.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07186414B2 |
| 出典データセット | uspto-grants-2007_03 |
| ORD ID | ord-04b72043e96b43279518ad408494aeec |
| 出典メモ | uspto-grants-2007_03 |