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Sodium borohydride → 9-cis-Retinol
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Sodium borohydride | HCID 4311764 | — |
| 反応物 | 9-Cis-Retinal | HCID 6436082 | — |
| 反応物 | (2Z,6E,8E)-3,5,7-trimethyl-9-(2,6,6-trimethylcyclohexen-1-yl)nona-2,6,8-trien-1-ol | HCID 57390897 | — |
| 生成物 | 9-cis-Retinol | HCID 9947823 | — |
反応手順
All-trans-retinol was obtained as a gift from Dr. Christian Eckhoff of Hoffmann-LaRoche, Inc. (Nutley, N.J.), and 13-cis-retinol was purchased from Sigma. 9-cis-Retinol was synthesized by NaBH4 reduction of authentic 9-cis-retinaldehyde (Sigma) and subsequently purified by normal phase HPLC essentially as we have described for 11-cis-retinol synthesis and purification (25). All-trans-, 13-cis-, and 9-cis-retinaldehydes were purchased from Sigma.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07186534B1 |
| 出典データセット | uspto-grants-2007_03 |
| ORD ID | ord-fed8c9324be34a5a8e6c9e26c2754501 |
| 出典メモ | uspto-grants-2007_03 |