Cyclopropylamine → N-cyclopropyl-2-hydroxybenzamide

HRID 456397ノート

反応式

HRID 456397 の反応式
C[O:2][C:3]1[C:4](=[CH:8][CH:9]=[CH:10][CH:11]=1)[C:5]([O-:7])=O.[CH:12]1([NH2:15])[CH2:14][CH2:13]1>C1(C)C=CC=CC=1>[CH:12]1([NH:15][C:5](=[O:7])[C:4]2[CH:8]=[CH:9][CH:10]=[CH:11][C:3]=2[OH:2])[CH2:14][CH2:13]1

参加物

4

反応物 2

HCID 69828Cyclopropylamine2 回HCID 69502182-Methoxybenzoate

生成物 1

HCID 822771N-cyclopropyl-2-hydroxybenzamide収率 53.3%

試薬・触媒・溶媒 1

HCID 1140Toluene溶媒

実験手順

A mixture of methylsalicylate (4.36 g, 28.69 mmol) and cyclopropylamine (1.64 g, 28.69 mmol) was heated at 80–100° C. for 3 h. An additional 0.5 equivalent of cyclopropylamine was added and the reaction mixture was kept at 70° C. for overnight. The reaction mixture was co-evaporated with toluene and the residue was purified by silica gel flash chromatography to give the subtitle compound (2.71 g).

後処理

  1. temperaturewas heated at 80–100° C. for 3 h
  2. customthe residue was purified by silica gel flash chromatography

出典と根拠

ORDレコード
ord-740826eff3a74334a73f1cecb41741a3
出典データセット
uspto-grants-2007_03
特許番号
US07186718B2

反応ノート

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