Nitrogen → 1-(2-Bromoethoxy)-2,4-difluorobenzene

HRID 456424ノート

反応式

HRID 456424 の反応式
[F:1][C:2]1[CH:11]=[C:10]([F:12])[CH:9]=[CH:8][C:3]=1[O:4][CH2:5][CH2:6]O.C1(P(C2C=CC=CC=2)C2C=CC=CC=2)C=CC=CC=1.C(Br)(Br)(Br)[Br:33].N#N>C(Cl)Cl.CCOC(C)=O>[Br:33][CH2:6][CH2:5][O:4][C:3]1[CH:8]=[CH:9][C:10]([F:12])=[CH:11][C:2]=1[F:1]

参加物

7

反応物 4

HCID 947NitrogenHCID 11205Carbon tetrabromideHCID 11776TriphenylphosphineHCID 18437003Ethanol, 2-(2,4-difluorophenoxy)-

生成物 1

HCID 232942611-(2-Bromoethoxy)-2,4-difluorobenzene

試薬・触媒・溶媒 2

HCID 6344Dichloromethane溶媒2 回HCID 8857Ethyl Acetate溶媒

実験手順

To a cool solution 2-(2,4-difluoro-phenoxy)-ethanol (0.48 g, 2.77 mmol.) in CH2Cl2 (15 ml), triphenyl phosphine (1.3 g, 5 mmol)) was added. Carbon tetrabromide (1.65 g, 5 mmol.) in CH2Cl2 (3 ml) was added to the solution dropwise under N2. The solution was stirred for 30 minutes. EtOAc was added, then the solvent was evaporated under reduced pressure.

後処理

  1. customthe solvent was evaporated under reduced pressure

出典と根拠

ORDレコード
ord-d2aed284c51e47ada2a87d9c5beb07e7
出典データセット
uspto-grants-2007_03
特許番号
US07186726B2

反応ノート

読み込み中…