Boron tribromide → 2-Bromo-3-fluorophenol
反応式
[Br:1][C:2]1[C:7]([F:8])=[CH:6][CH:5]=[CH:4][C:3]=1[O:9]C.B(Br)(Br)Br>C(Cl)Cl>[Br:1][C:2]1[C:7]([F:8])=[CH:6][CH:5]=[CH:4][C:3]=1[OH:9]参加物
4
反応条件
- 温度
- -78 °C
実験手順
2-Bromo-3-fluoro anisole (10 g, 48.77 mmol) was dissolved in DCM (200 mL) and cooled to about −78° C. To the solution was added BBr3 (11.53 mL, 121.9 mmol) in one portion. The mixture was warmed to r.t. and stirred overnight. The mixture was partitioned between water and DCM (50 mL), and the aqueous layer was back extracted with DCM (200 mL). The combined organics were dried (NaSO4), filtered and concentrated to give about 9.32 g of the product as a dark oil. MS found 188.9 (M−1)
後処理
- temperatureThe mixture was warmed to r.t.
- customThe mixture was partitioned between water and DCM (50 mL)
- extractionthe aqueous layer was back extracted with DCM (200 mL)
- dry with materialThe combined organics were dried (NaSO4)
- filtrationfiltered
- concentrationconcentrated
出典と根拠
- ORDレコード
- ord-54439269130d44049780b801b96807af
- 出典データセット
- uspto-grants-2007_03
- 特許番号
- US07186715B2
反応ノート
読み込み中…