Acetyl chloride → 1-(4-Hydroxypiperidin-1-yl)ethan-1-one

HRID 456446ノート

反応式

HRID 456446 の反応式
[OH:1][CH:2]1[CH2:7][CH2:6][NH:5][CH2:4][CH2:3]1.C(N(CC)CC)C.[C:15](Cl)(=[O:17])[CH3:16]>C(Cl)Cl>[OH:1][CH:2]1[CH2:7][CH2:6][N:5]([C:15](=[O:17])[CH3:16])[CH2:4][CH2:3]1

参加物

5

反応物 3

HCID 6367Acetyl chlorideHCID 8471TriethylamineHCID 79341Piperidin-4-ol

生成物 1

HCID 107492911-(4-Hydroxypiperidin-1-yl)ethan-1-one収率 80%

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

反応条件

温度
-78 °C

実験手順

4-hydroxypiperidine (0.534 g, 5.3 mmol) was dissolved in methylene chloride (50 mL). The solution was cooled to −78° C. and triethylamine (1.10 mL, 7.95 mmol) was added. Acetyl chloride (0.33 mL, 4.77 mmol) was added dropwise to the mixture. The mixture was warmed to r.t., concentrated under reduced pressure and purified using silica gel chromatography (50% ethyl acetate in hexanes) to give the title compound (0.540 g, 80%) as an oil.

後処理

  1. temperatureThe mixture was warmed to r.t.
  2. concentrationconcentrated under reduced pressure
  3. custompurified

出典と根拠

ORDレコード
ord-933c51307fc34f10a9c99671f521d0db
出典データセット
uspto-grants-2007_03
特許番号
US07186715B2

反応ノート

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