Methylcyclohexane → (1S,2S)-2-methoxycarbonylcyclopropanecarboxylic acid
反応式
[CH3:1][O:2][C:3]([C@@H:5]1[CH2:7][C@H:6]1[C:8]([OH:10])=[O:9])=[O:4].COC1C=CC2N=CC=C([C@@H](O)[C@H]3N4C[C@H](C=C)[C@@H](CC4)C3)C=2C=1.CC1CCCCC1>CC(C)=O>[CH3:1][O:2][C:3]([C@H:5]1[CH2:7][C@@H:6]1[C:8]([OH:10])=[O:9])=[O:4]参加物
5
実験手順
Add trans-cyclopropane-1,2-dicarboxylic acid monomethyl ester, Example 3a, (19.46 g) in acetone to quinine (43.8 g) in one portion. Heat the reaction to reflux, and then add methylcyclohexane (150 mL). After crystallization (5 times) from acetone/methylcyclohexane, collect 6.2 g of the diastereomeric salt (αD:+173, c:7.3 CHCl3)
後処理
- temperatureHeat
- customthe reaction
- temperatureto reflux
- customAfter crystallization (5 times) from acetone/methylcyclohexane
- customcollect 6.2 g of the diastereomeric salt (αD:+173, c:7.3 CHCl3)
出典と根拠
- ORDレコード
- ord-cab5625791944481b134ae2d9921a211
- 出典データセット
- uspto-grants-2007_03
- 特許番号
- US07186724B2
反応ノート
読み込み中…