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4-(6-Methoxy-[1,5]naphthyridin-4-ylcarbamoyl)-piperidine-1-carboxylic acid benzyl ester → Piperidine-4-carboxylic acid (6-methoxy-[1,5]naphthyridin-4-yl)-amide
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 4-(6-Methoxy-[1,5]naphthyridin-4-ylcarbamoyl)-piperidine-1-carboxylic acid benzyl ester | HCID 11247158 | — |
| 触媒 | Palladiumcarbon | HCID 14818447 | — |
| 溶媒 | Ethanol ethylacetate | HCID 21584252 | — |
| 生成物 | Piperidine-4-carboxylic acid (6-methoxy-[1,5]naphthyridin-4-yl)-amide | HCID 11231497 | 59% |
反応手順
A solution of (e) (6.0 g, 14.3 mmol) in ethanol/ethyl acetate (150 ml/150 ml) was hydrogenated over 10% Pd/charcoal (5 g) for 1.5 hours. Filtration, washing with ethanol (400 ml) and evaporation of the filtrate gave a white solid (2.4 g, 59%).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07186730B2 |
| 出典データセット | uspto-grants-2007_03 |
| ORD ID | ord-62de4b780e9d4801979ff0c701b6f06c |
| 出典メモ | uspto-grants-2007_03 |