Triethylamine → 3,4-Methylenedioxyphenethyl mesylate

HRID 456587ノート

反応式

HRID 456587 の反応式
[O:1]1[C:5]2[CH:6]=[CH:7][C:8]([CH2:10][CH2:11][OH:12])=[CH:9][C:4]=2[O:3][CH2:2]1.C(N(CC)CC)C.[CH3:20][S:21](Cl)(=[O:23])=[O:22]>ClCCl>[O:1]1[C:5]2[CH:6]=[CH:7][C:8]([CH2:10][CH2:11][O:12][S:21]([CH3:20])(=[O:23])=[O:22])=[CH:9][C:4]=2[O:3][CH2:2]1

参加物

5

反応物 3

HCID 8471TriethylamineHCID 31297Methanesulfonyl chlorideHCID 27598462-(1,3-Dioxaindan-5-yl)ethan-1-ol

生成物 1

HCID 186255853,4-Methylenedioxyphenethyl mesylate収率 100.5%

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

A solution of alcohol (a) (1.90 g, 11 mmol) in dichloromethane (25 ml) was treated at 0° C. with triethylamine (1.9 ml, 13.7 mmol) and methanesulfonyl chloride (1.1 ml, 13.7 mmol). After 1.5 hours at room temperature the mixture was partitioned between dichloromethane and water. The organic extract was dried and evaporated to give a yellow oil (2.7 g, 96%).

後処理

  1. customAfter 1.5 hours at room temperature the mixture was partitioned between dichloromethane and water
  2. extractionThe organic extract
  3. customwas dried
  4. customevaporated

出典と根拠

ORDレコード
ord-411bf821d8784d468f227ada430abb2a
出典データセット
uspto-grants-2007_03
特許番号
US07186730B2

反応ノート

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